Our research comprises a program of NIH-funded clinical and translational research into a range of lung diseases including asthma, chronic obstructive pulmonary disease (COPD), and granulomatous lung diseases (e.g. sarcoidosis and hypersensitivity pneumonitis). These studies fall into three specific categories: 1) the identification of distinct molecular sub-phenotypes of these diseases, 2) the elucidation of disease-relevant mechanisms of airway inflammation and remodeling in the lung and 3) clinical trials of novel therapeutic approaches.