Recent publications

 


1. Multicohort Analysis of Bronchial Epithelial Cell Expression in Healthy Subjects and Patients with Asthma Reveals Four Clinically Distinct Clusters

Am J Respir Cell Mol Biol. 2024 Dec 19.
Lee I, Ganesan A, Kalesinskas L, Zheng H, Ahn HC, Christenson S, Erzurum SC, Zein J, Bleecker ER, Meyers DA, Castro M, Fahy JV, Israel E, Jarjour NN, Moore W, Wenzel SE, Mauger DT, Levy BD, Woodruff PG, Ortega VE, Khatri P.
PMID: 39700523
View in PubMed: Link
Fields: Cel, Mol


2. Association of Ground-Glass Opacities with Systemic Inflammation and Progression of Emphysema

Am J Respir Crit Care Med. 2024 Dec 15; 210(12):1432-1440.
Fortis S, Guo J, Nagpal P, Chaudhary MFA, Newell JD, Gerard SE, Han MK, Kazerooni EA, Martinez FJ, Barjaktarevic IZ, Barr RG, Bodduluri S, Paine R, Awan HA, Schroeder JD, Gravens-Mueller LD, Ortega VE, Anderson WH, Cooper CB, Couper D, Woodruff PG, Bowler RP, Bhatt SP, Hoffman EA, Reinhardt JM, Comellas AP.
PMID: 38843116
View in PubMed: Link
Mentions: Article has an altmetric score of 20
Fields: Cri, Pul


3. Increased Muc5AC and Decreased Ciliated Cells in Severe Asthma Partially Restored by Inhibition of IL-4Rα Receptor

Am J Respir Crit Care Med. 2024 Dec 15; 210(12):1409-1420.
Boomer J, Choi J, Alsup A, McGregor MC, Lieu J, Johnson C, Hall C, Shi X, Kim T, Goss C, Lew D, Christensen S, Woodruff P, Hastie A, Mauger D, Wenzel SE, Hoffman E, Schechtman KB, Castro M.
PMID: 38935626
View in PubMed: Link
Mentions: Article has an altmetric score of 19
Fields: Cri, Pul


4. Dysanapsis Genetic Risk Predicts Lung Function Across the Lifespan

Am J Respir Crit Care Med. 2024 Dec 15; 210(12):1421-1431.
Debban CL, Ambalavanan A, Ghosh A, Li Z, Buschur KL, Ma Y, George E, Pistenmaa C, Bertoni AG, Oelsner EC, Michos ED, Moraes TJ, Jacobs DR, Christenson S, Bhatt SP, Kaner RJ, Simons E, Turvey SE, Vameghestahbanati M, Engert JC, Kirby M, Bourbeau J, Tan WC, Gabriel SB, Gupta N, Woodruff PG, Subbarao P, Ortega VE, Bleecker ER, Meyers DA, Rich SS, Hoffman EA, Barr RG, Cho MH, Bossé Y, Duan Q, Manichaikul A, Smith BM.
PMID: 38935874
View in PubMed: Link
Mentions: Article has an altmetric score of 3
Fields: Cri, Pul, Translation:Humans


5. Type 1 Immune Responses Related to Viral Infection Influence Corticosteroid Response in Asthma

Am J Respir Crit Care Med. 2024 Nov 27.
Fahy JV, Jackson ND, Sajuthi SP, Pruesse E, Moore CM, Everman JL, Rios C, Tang M, Gauthier M, Wenzel SE, Bleecker ER, Castro M, Comhair SA, Erzurum SC, Hastie AT, Moore W, Israel E, Levy BD, Denlinger L, Jarjour NN, Johansson MW, Mauger DT, Phillips BR, Sumino K, Woodruff PG, Peters MC, Seibold MA, National Heart, Lung, and Blood Institute Severe Asthma Research Program-3.
PMID: 39601762
View in PubMed: Link
Mentions: Article has an altmetric score of 6
Fields: Cri, Pul


6. Phenotypes and Trajectories of Tobacco-exposed Persons with Preserved Spirometry: Insights from Lung Volumes

Ann Am Thorac Soc. 2024 Nov 25.
Arjomandi M, Zeng S, Barjaktarevic I, Bleecker ER, Bowler RP, Criner GJ, Comellas AP, Couper DJ, Curtis JL, Dransfield MT, Drummond MB, Fortis S, Han MK, Hansel NN, Hoffman EA, Kaner RJ, Kanner RE, Krishnan JA, Labaki W, Ortega VE, Peters SP, Rennard SI, Cooper CB, Tashkin DP, Paine R, Woodruff PG.
PMID: 39586032
View in PubMed: Link
Mentions: Article has an altmetric score of 3
Fields: Pul


7. Development of an asthma health-care burden score as a measure of severity and predictor of remission in SARP III and U-BIOPRED: results from two major longitudinal asthma cohorts

Lancet Respir Med. 2024 Nov 22.
Zein JG, Zounemat-Kerman N, Adcock IM, Hu B, Attaway A, Castro M, Dahlén SE, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Hastie AT, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore W, Peters MC, Sumino K, Townsend E, Woodruff P, Ortega VE, Wenzel SE, Meyers DA, Chung KF, Bleecker ER, Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) Consortium and th.
PMID: 39586307
View in PubMed: Link
Mentions: Article has an altmetric score of 41
Fields: Pul


8. Radiomultiomics: pioneering precision medicine for severe asthma

Eur Respir J. 2024 Nov; 64(5).
Polverino F, Woodruff PG.
PMID: 39572207
View in PubMed: Link
Mentions: Article has an altmetric score of 2
Fields: Pul


9. The Effect of Chronic Altitude Exposure on Chronic Obstructive Pulmonary Disease Outcomes in the SPIROMICS Cohort: An Observational Cohort Study

Am J Respir Crit Care Med. 2024 Nov 15; 210(10):1210-1218.
Suri R, Markovic D, Woo H, Arjomandi M, Barr RG, Bowler RP, Criner G, Curtis JL, Dransfield MT, Drummond MB, Fortis S, Han MK, Hoffman EA, Kaner RJ, Kaufman JD, Krishnan JA, Martinez FJ, Ohar J, Ortega VE, Paine R, Soler X, Woodruff PG, Hansel NN, Cooper CB, Tashkin DP, Buhr RG, Barjaktarevic IZ.
PMID: 38507607
View in PubMed: Link
Mentions: Article has an altmetric score of 6
Fields: Cri, Pul


10. Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia

Nat Commun. 2024 Oct 29; 15(1):9339.
Spottiswoode N, Tsitsiklis A, Chu VT, Phan HV, DeVoe C, Love C, Ghale R, Bloomstein J, Zha BS, Maguire CP, Glascock A, Sarma A, Mourani PM, Kalantar KL, Detweiler A, Neff N, Haller SC, COMET Consortium, DeRisi JL, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Matthay MA, Woodruff PG, Calfee CS, Langelier CR.
PMID: 39472555
View in PubMed: Link
Mentions: Article has an altmetric score of 57
Fields: Bio, Sci, Translation:HumansCells


11. Serum Immunoglobulin G Levels Are Associated with Risk for Exacerbations: An Analysis of SPIROMICS

Am J Respir Crit Care Med. 2024 Oct 23.
Burnim M, Putcha N, LaFon D, Woo H, Azar A, Groenke L, Stampfli M, Schaub A, Fawzy A, Balasubramanian A, Fedarko N, Cooper CB, Bowler RP, Comellas A, Krishnan JA, Han MK, Couper D, Peters SP, Drummond MB, O'Neal W, Paine R, Criner G, Martinez FJ, Curtis JL, Barr G, Huang YJ, Woodruff P, Dransfield M, Hansel NN.
PMID: 39441116
View in PubMed: Link
Fields: Cri, Pul


12. Design of the SPIROMICS Study of Early COPD Progression: SOURCE Study

Chronic Obstr Pulm Dis. 2024 Sep 27; 11(5):444-459.
Curtis JL, Bateman LA, Murray S, Couper DJ, Labaki WW, Freeman CM, Arnold KB, Christenson SA, Alexis NE, Kesimer M, Boucher RC, Kaner RJ, Barjaktarevic I, Cooper CB, Hoffman EA, Barr RG, Bleecker ER, Bowler RP, Comellas A, Dransfield MT, Freedman MB, Hansel NN, Krishnan JA, Marchetti N, Meyers DA, Ohar J, O'Neal WK, Ortega VE, Paine Iii R, Peters SP, Smith BM, Wedzicha JA, Wells JM, Woodruff PG, Han MK, Martinez FJ.
PMID: 39159077
PMCID: PMC11548966
View in PubMed: Link
Mentions: Article has an altmetric score of 31
Fields:


13. Epigenetic patient stratification via contrastive machine learning refines hallmark biomarkers in minoritized children with asthma

Res Sq. 2024 Sep 13.
Gorla A, Witonsky J, Elhawary JR, Chen ZJ, Mefford J, Perez-Garcia J, Huntsman S, Hu D, Eng C, Woodruff PG, Sankararaman S, Ziv E, Flint J, Zaitlen N, Burchard E, Rahmani E.
PMID: 39315258
PMCID: PMC11419268
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Fields:


14. Air Pollution Exposure and Interstitial Lung Features in SPIROMICS Participants with Chronic Obstructive Pulmonary Disease

Ann Am Thorac Soc. 2024 Sep; 21(9):1251-1260.
Baddour NA, Paulin LM, Gassett AJ, Woo H, Hoffman EA, Newell JD, Woodruff PG, Pirozzi CS, Barjaktarevic I, Barr RG, O'Neal W, Han MK, Martinez FJ, Peters SP, Hastie AT, Hansel NN, Ortega VE, Kaufman JD, Sack CS.
PMID: 38568439
PMCID: PMC11376362
View in PubMed: Link
Mentions: Article has an altmetric score of 1
Fields: Pul


15. Genetic Architecture and Analysis Practices of Circulating Metabolites in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

bioRxiv. 2024 Aug 26.
Wang N, Ockerman FP, Zhou LY, Grove ML, Alkis T, Barnard J, Bowler RP, Clish CB, Chung S, Drzymalla E, Evans AM, Franceschini N, Gerszten RE, Gillman MG, Hutton SR, Kelly RS, Kooperberg C, Larson MG, Lasky-Su J, Meyers DA, Woodruff PG, Reiner AP, Rich SS, Rotter JI, Silverman EK, Ramachandran VS, Weiss ST, Wong KE, Wood AC, Wu L, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Yarden R, Blackwell TW, Smith AV, Chen H, Raffield LM, Yu B.
PMID: 39211135
PMCID: PMC11361093
View in PubMed: Link
Mentions: Article has an altmetric score of 3
Fields:


16. Advances in non-type 2 severe asthma: from molecular insights to novel treatment strategies

Eur Respir J. 2024 Aug; 64(2).
Liu T, Woodruff PG, Zhou X.
PMID: 38697650
PMCID: PMC11325267
View in PubMed: Link
Mentions: Article has an altmetric score of 15
Fields: Pul, Translation:HumansCells


17. IL-13 and IL-17A activate β1 integrin through an NF-kB/Rho kinase/PIP5K1γ pathway to enhance force transmission in airway smooth muscle

Proc Natl Acad Sci U S A. 2024 Aug 20; 121(34):e2401251121.
Ngo U, Shi Y, Woodruff P, Shokat K, DeGrado W, Jo H, Sheppard D, Sundaram AB.
PMID: 39136993
PMCID: PMC11348015
View in PubMed: Link
Mentions: Article has an altmetric score of 1
Fields: Sci, Translation:HumansAnimalsCells


18. Dynamic and prognostic proteomic associations with FEV1 decline in chronic obstructive pulmonary disease

medRxiv. 2024 Aug 08.
Ruvuna L, Hijazi K, Guzman DE, Guo C, Loureiro J, Khokhlovich E, Morris M, Obeidat M, Pratte KA, DiLillo KM, Sharma S, Kechris K, Anzueto A, Barjaktarevic I, Bleecker ER, Casaburi R, Comellas A, Cooper CB, DeMeo DL, Foreman M, Flenaugh EL, Han MK, Hanania NA, Hersh CP, Krishnan JA, Labaki WW, Martinez FJ, O'Neal WK, Paine R, Peters SP, Woodruff PG, Wells JM, Wendt CH, Arnold KB, Barr RG, Curtis JL, Ngo D, Bowler RP, SPIROMICS, COPDGene and MESA-Lung Investigators.
PMID: 39148837
PMCID: PMC11326337
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Fields:


19. Immediate myeloid depot for SARS-CoV-2 in the human lung

Sci Adv. 2024 Aug 02; 10(31):eadm8836.
Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Bernard O, Simoneau CR, Hysenaj L, Hu KH, Maishan M, Conrad C, Gbenedio OM, Samad B, Consortium TUC, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR.
PMID: 39083602
PMCID: PMC11290487
View in PubMed: Link
Mentions: Article has an altmetric score of 18
Fields: Sci, Translation:HumansCells


20. Loss of Airway Phylogenetic Diversity Is Associated with Clinical and Pathobiological Markers of Disease Development in Chronic Obstructive Pulmonary Disease

Am J Respir Crit Care Med. 2024 07 15; 210(2):186-200.
Opron K, Begley LA, Erb-Downward JR, Li G, Alexis NE, Barjaktarevic I, Barr RG, Bleecker ER, Boucher R, Bowler RP, Christenson SA, Comellas AP, Criner GJ, Cooper CB, Couper D, Galban CJ, Han MK, Hastie A, Hatt C, Hoffman EA, Kaner RJ, Kesimer M, Krishnan JA, LaFon DC, Martinez FJ, Ortega VE, Peters SP, Paine R, Putcha N, Woodruff PG, Huffnagle GB, Kozik AJ, Curtis JL, Huang YJ, SPIROMICS Investigators.
PMID: 38261629
PMCID: PMC11273318
View in PubMed: Link
Mentions: Article has an altmetric score of 4
Fields: Cri, Pul


21. Estimating ambient air pollutant concentrations outside and inside homes in the Subpopulations and Intermediate outcomes in COPD air pollution (SPIROMICS air) cohort

Environ Res. 2024 Oct 15; 259:119512.
Kirwa K, Gassett AJ, Sack C, Paulin LM, Pirozzi CS, Barr RG, Woodruff PG, Han M, Wilgus ML, Barjaktarevic I, Peters S, Hansel NN, Kaufman JD.
PMID: 38964581
PMCID: PMC11365799
View in PubMed: Link
Fields: Env, Translation:HumansPH


22. Vessel and Airway Characteristics in One-Year Computed Tomography-defined Rapid Emphysema Progression: SPIROMICS

Ann Am Thorac Soc. 2024 Jul; 21(7):1022-1033.
Gerard SE, Dougherty TM, Nagpal P, Jin D, Han MK, Newell JD, Saha PK, Comellas AP, Cooper CB, Couper D, Fortis S, Guo J, Hansel NN, Kanner RE, Kazeroni EA, Martinez FJ, Motahari A, Paine R, Rennard S, Schroeder JD, Woodruff PG, Barr RG, Smith BM, Hoffman EA, SPIROMICS Research Group.
PMID: 38530051
PMCID: PMC11284327
View in PubMed: Link
Mentions:
Fields: Pul


23. Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19

Nat Commun. 2024 Jun 28; 15(1):5483.
Neyton LPA, Patel RK, Sarma A, UCSF COMET Consortium, Willmore A, Haller SC, Kangelaris KN, Eckalbar WL, Erle DJ, Krummel MF, Hendrickson CM, Woodruff PG, Langelier CR, Calfee CS, Fragiadakis GK.
PMID: 38942804
PMCID: PMC11213873
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Mentions: Article has an altmetric score of 5
Fields: Bio, Sci, Translation:HumansCells


24. Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort

JCI Insight. 2024 Jun 24; 9(12).
Zhang WZ, Rice MC, Hoffman KL, Oromendia C, Barjaktarevic IZ, Wells JM, Hastie AT, Labaki WW, Cooper CB, Comellas AP, Criner GJ, Krishnan JA, Paine R, Hansel NN, Bowler RP, Barr RG, Peters SP, Woodruff PG, Curtis JL, Han MK, Ballman KV, Martinez FJ, Choi AM, Nakahira K, Cloonan SM, Choi ME, SPIROMICS Investigators.
PMID: 38912587
PMCID: PMC11383142
View in PubMed: Link
Fields: Med, Translation:Humans


25. Peroxidase-mediated mucin cross-linking drives pathologic mucus gel formation in IL-13-stimulated airway epithelial cells

JCI Insight. 2024 Jun 18; 9(15).
Liegeois MA, Braunreuther M, Charbit AR, Raymond WW, Tang M, Woodruff PG, Christenson SA, Castro M, Erzurum SC, Israel E, Jarjour NN, Levy BD, Moore WC, Wenzel SE, Fuller GG, Fahy JV.
PMID: 38889046
PMCID: PMC11383604
View in PubMed: Link
Fields: Med, Translation:HumansCells