Recent publications

TOP PUBLICATIONS (PEER-REVIEWED + PREPRINTS)

  1. Kim JS, Debban CL, Guzman DE, Hannan RT, Salvatore M, McGroder C, Zhang D, Podolanczuk AJ, Duprez DA, Ma SF, Huang Y, Sturek JM, Rich SS, Rotter JI, Deo R, Dubin RF, Pugashetti JV, Wang JM, Han MK, Oldham JM, Noth I, Woodruff PG, Ortega VE, Fanburg-Smith JC, Stelow EB, Moskaluk CA, Hoffman EA, Garcia CK, Bowler RP, Ganz P, Barr RG, Manichaikul A. Associations of High Attenuation Area-Related Proteomic Biomarkers with Fibrotic or Subpleural Interstitial Lung Abnormalities. Am J Respir Crit Care Med. 2025 Oct;211(10):1811–1822. PMID: 40845333.

  2. LaHue SC, Takegami N, Simmasalam R, Baqai A, Munoz E, Sikri A, de Courson TDB, Singhal NS, Eckalbar W, Langelier CR, Hendrickson CM, Calfee CS, Erle DJ, Krummel MF, Woodruff PG, Oskotsky T, Sirota M, Ferguson A, Douglas VC, Newman JC, Pleasure SJ, Wilson MR, Singhal NS. Delirium in hospitalized COVID-19 patients is associated with dynamic changes in peripheral immune gene expression. Geroscience. 2025 Sep 22. PMID: 40982210.

  3. Wang N, Ockerman FP, Zhou LY, Grove ML, Alkis T, Barnard J, Bowler RP, Clish CB, Chung S, Drzymalla E, Evans AM, Franceschini N, Gerszten RE, Gillman MG, Hutton SR, Kelly RS, Kooperberg C, Larson MG, Lasky-Su J, Meyers DA, Woodruff PG, Reiner AP, Rich SS, Rotter JI, Silverman EK, Vasan RS, Weiss ST, Wong KE, Wood AC, Wu L, NHLBI TOPMed Consortium, Yarden R, Blackwell TW, Smith AV, Chen H, Raffield LM, Yu B. Genetic architecture and analysis practices of circulating metabolites in the NHLBI Trans-Omics for Precision Medicine Program. Am J Hum Genet. 2025 Sep 18. PMID: 40972578.

  4. Hoesterey DT, Dang H, Markovic D, Buhr RG, Tashkin DP, Barr RG, Belperio JA, Bowler RP, Bleecker ER, Couper DJ, Criner GG, Cooper CB, Doerschuk CM, Dransfield MT, Drummond MB, Fawzy A, Freeman CM, Han MK, Hansel NN, Hastie AT, Hoffman EA, Huang YJ, Kaner RJ, Kanner RE, Kim V, Krishnan JA, Martinez FJ, O’Neal WK, Ortega VE, Paine R, Shrivastav AK, Wells JM, Woodruff PG, Curtis JL, Barjaktarevic I. Neutrophil-to-Lymphocyte Ratio (NLR) as a Biomarker in Clinically Stable Chronic Obstructive Pulmonary Disease: SPIROMICS cohort. Ann Am Thorac Soc. 2025 Sep 08. PMID: 40920896.

  5. Gorla A, Witonsky J, Chen ZJ, Elhawary JR, Mefford J, Perez-Garcia J, Madore AM, Huntsman S, Hu D, Eng C, Bhakta NR, Woodruff PG, Laprise C, Sankararaman S, Flint J, Allen CDC, Ziv E, Zaitlen N, Burchard E, Rahmani E. Epigenetic patient stratification reveals a sub-endotype of type 2 asthma with altered B-cell response. medRxiv. 2025 Sep 02. PMID: 40950420; PMCID: PMC12424920.

  6. Azad Rabby AS, Chaudhary MFA, Saha P, Sthanam V, Nakhmani A, Zhang C, Graham Barr R, Bon J, Cooper CB, Curtis JL, Hoffman EA, Paine R, Puliyakote AK, Schroeder JD, Sieren JC, Smith BM, Woodruff PG, Reinhardt JM, Bhatt SP, Bodduluri S. Light Convolutional Neural Network to Detect Chronic Obstructive Pulmonary Disease (COPDxNet): A Multicenter Model Development and External Validation Study. medRxiv. 2025 Aug 01. PMID: 40766163; PMCID: PMC12324643.

  7. Buhr RG, Jackson NJ, Fazio JC, Barjaktarevic I, Bateman LA, Bhatt SP, Couper DJ, Curtis JL, Dolezal BA, Drummond MB, Han MK, Hansel NN, Iyer AS, Krishnan JA, Martinez FJ, Ohar J, Paine R, Rennard SI, Smith BM, Tashkin DP, Woodruff PG, Anderson WH, Cooper CB; SPIROMICS investigators. Characteristics Associated with Lung Function Trajectories: An Analysis of the SPIROMICS Cohort. Ann Am Thorac Soc. 2025 Aug;22(8):1165–1175. PMID: 40198759; PMCID: PMC12329327.

  8. Tejwani V, Putcha N, Woo H, Liu C, Lafon D, Alexis NE, Azar A, Barr RG, Barjaktarevic I, Bowler RP, Comellas A, Couper DJ, Fawzy A, Han MK, Hansel NN, Kaner RJ, Krishnan JA, Marchetti N, Martinez FJ, Ohar J, O’Neal W, Ortega VE, Paine III R, Pottinger TD, Stämpfli M, Ruvuna L, Woodruff PG, Freeman CM, Huang YJ, Curtis JL. Associations of serum and bronchoalveolar immunoglobulins with lung microbiota diversity, B-cell memory phenotypes, and COPD morbidity and exacerbations. Respir Res. 2025 Jul 18;26(1):250. PMID: 40682114; PMCID: PMC12275290.

  9. Guzman DE, Ruvuna L, Guo CJ, Sun Y, Pratte KA, Manichaikul AW, Kim JS, Post WS, Bertoni AG, Allen NB, Watson KE, Pankow JS, Hoffman EA, Dubin RF, Deo R, Barjaktarevic IZ, Bleecker ER, Cooper CB, Ortega VE, Hastie AT, Paine R, Wells JM, Curtis JL, Silverman EK, Woodruff PG, Garcia CK, Rotter JI, Bowler RP, Ganz P, Barr RG. Proteomic discovery analysis of quantitatively assessed emphysema in the general population (MESA Lung). Respir Res. 2025 Jul 04;26(1):236. PMID: 40616090; PMCID: PMC12228189.

  10. Ogungbe O, Wang T, Balte PP, Slone SE, Meyer D, Allen NB, Buhr RG, Hirsch JA, Hinckley Stukovsky K, Kucharska-Newton A, Gabriel KP, Regan EA, Xanthakis V, Isasi CR, Talavera G, Daviglus M, Perreira KM, Sims M, Contreras JG, Kandula NR, Lee JS, Howard VJ, Judd SE, Woodruff P, Ortega VE, Fretts AM, Wenzel SE, Phipatanakul W, Putcha N, Hansel N, Oelsner E, Post WS. Self-Reported Resilience During the COVID-19 Pandemic. JAMA Netw Open. 2025 Jul 01;8(7):e2520360. PMID: 40668582; PMCID: PMC12268485.

  11. Balte PP, Kim JS, Sun Y, Allen N, Angelini E, Arynchyn A, Barr RG, Blaha M, Bowler R, Carr J, Cole SA, Couper D, Demmer RT, Doyle M, Elkind M, San José Estépar R, Garcia-Bedoya O, Garudadri S, Hansel NN, Hermann EA, Hoffman EA, Humphries SM, Hunninghake GM, Kaplan R, Krishnan JA, Laine A, Lee JS, Lynch DA, Make B, Matsushita K, McKleroy W, Min YI, Naik SN, O’Connor G, O’Driscoll O, Oren E, Podolanczuk AJ, Post WS, Pottinger T, Regan E, Rusk A, Salvatore M, Schwartz DA, Smith B, Sotres-Alvarez D, Umans JG, Vasan RS, Washko G, Wenzel S, Woodruff P, Xanthakis V, Ortega VE, Oelsner EC. Associations of Prepandemic Lung Function and Structure with COVID-19 Outcomes: The C4R Study. Am J Respir Crit Care Med. 2025 Jul;211(7):1196–1210. PMID: 40238945; PMCID: PMC12264703.

  12. Barjaktarevic I, Hixson R, Zhuang Z, Buhr RG, Tejwani V, Barr RG, Bateman LA, Bhatt SP, Bleecker ER, Cooper CB, Curtis JL, Drummond MB, Fortis S, Ghosh AJ, Han M, Hansel NN, Hoffman EA, Ohar J, Martinez FJ, Meyers DA, Paine R, Pirozzi CS, Sandhaus R, Strange C, Tashkin DP, Wells JM, Woodruff P, Ortega VE. Longitudinal Outcomes in Pi*MZ Alpha-1 Antitrypsin-Deficient Individuals with Tobacco Smoking History from the SPIROMICS Cohort. Ann Am Thorac Soc. 2025 Jul;22(7):998–1008. PMID: 40068143; PMCID: PMC12254153.

  13. Jayavelu ND, Qi J, Milliren CE, Ozonoff A, Liu S, Levy O, Baden LR, Melamed E, McComsey GA, Cairns CB, Schaenman J, Shaw AC, Hafler DA, Corry DB, Kheradmand F, Atkinson MA, Brakenridge SC, Agudelo Higuita NI, Metcalf JP, Hough CL, Messer WB, Pulendran B, Nadeau KC, Davis MM, Geng LN, Sesma AF, Simon V, Krammer F, Bime C, Calfee CS, Bosinger SE, Eckalbar W, Steen H, Maecker HT, IMPACC Network, Augustine AD, Diray-Arce J, Haddad EK, Sekaly RP, Kraft M, Woodruff PG, Erle DJ, Ehrlich LIR, Montgomery RR, Becker PM, Altman MC, Fourati S. Type 2 immune responses are associated with less severe COVID-19 in a hospitalized cohort. J Allergy Clin Immunol Glob. 2025 Nov;4(4):100515. PMID: 40709330; PMCID: PMC12284355.

  14. Konigsberg IR, Vargas LB, Pratte KA, Guzman DE, Pottinger TD, Buschur KL, Blackwell TW, Liu Y, Taylor KD, Johnson WC, Durda P, Tracy RP, Manichaikul A, Oelsner EC, Gabriel S, Gupta N, Onengut-Gumuscu S, Smith JD, Aguet F, Ardlie KG, Tahir UA, Gerszten RE, Clish C, Bleecker ER, Meyers DA, Ortega VE, Christenson SA, DeMeo DL, Hobbs BD, Hersh CP, Castaldi PJ, Curtis JL, Barr RG, Rotter JI, Rich SS, Woodruff PG, Silverman EK, Cho MH, Kechris KJ, Bowler RP, Lange EM, Lange LA, Moll MR. Omic Risk Scores are Associated with COPD-related Traits Across Three Cohorts. medRxiv. 2025 Jun 02. PMID: 40502581; PMCID: PMC12155009.

  15. Narendra R, Lydon EC, Van Phan H, Spottiswoode N, Neyton LP, Diray-Arce J, IMPACC Network, COMET Consortium, EARLI Consortium, Becker PM, Kim-Schulze S, Hoch A, Pickering H, van Zalm P, Cairns CB, Altman MC, Augustine AD, Bosinger S, Eckalbar W, Guan L, Jayavelu ND, Kleinstein SH, Krammer F, Maecker HT, Ozonoff A, Peters B, Rouphael N, Montgomery RR, Reed E, Schaenman J, Steen H, Levy O, Carillo SA, Erle D, Hendrickson CM, Krummel MF, Matthay MA, Woodruff P, Haddad EK, Calfee CS, Langelier CR. Minimalistic Transcriptomic Signatures Permit Accurate Early Prediction of COVID-19 Mortality. medRxiv. 2025 May 19. PMID: 40475132; PMCID: PMC12140511.

CONFERENCE ABSTRACTS (AJRCCM, May 1, 2025)
16) Ortega OV, Chen CX, Shrivastav SA, Zein ZJ, Howard HT, Hawkins HG, Barjaktarevic BI, Bowler BR, Barr BR, Comellas CA, Cooper CC, Couper CD, Galban GC, Han HM, Hansel HN, Hastie HA, Kaner KR, Kanner KR, Martinez MF, O’Neal OW, Paine PR, Hoffman HE, Meyers MD, Woodruff WP, Curtis CJ, Bleecker BE, Huang HY, Christenson CS, NHLBI Subpopulations and Intermediate Outcomes Measures in C N. Epigenomic and Transcriptomic Regulation of the MUC5B/MUC5AC Locus in Bronchial Airway Epithelium and Association With Early Small Airways Disease in Spiromics. Am J Respir Crit Care Med. 211(Abstracts):a5245–a5245.

  1. Gandhi GS, Fazio FJ, Vergara VX, Harrison HR, Reynolds RC, Thakur TN, Woodruff WP, Cummings CK. Pulmonary Fibrosis Mortality by Industry – California 2017–19. Am J Respir Crit Care Med. 211(Abstracts):a6302–a6302.

  2. Oh OA, Niederhuber NM, Jones JC, Brennan BT, Liu LH, Currin CK, Kennedy KS, Christenson CS, Couper CD, Barjaktarevic BI, Barr BR, Bon BJ, Bowler BR, Comellas CA, Cooper CC, Han HM, Hansel HN, Kaner KR, Krishnan KJ, Martinez MF, Marchetti MN, Onofrei OC, Ortega OV, Paine PR, Wells WJ, Woodruff WP, SPIROMICS Investigators. Differences in Airway Epithelial Gene Expression in Resilient vs Non-resilient Smokers. Am J Respir Crit Care Med. 211(Abstracts):a7375–a7375.

  3. Baugh BA, Aronica AM, Castro CM, Denlinger DL, Hastie HA, Jarjour JN, Levy LB, Mauger MD, Phillips PB, Sumino SK, Woodruff WP, Thakur TN, Sheshadri SA. Race-neutral Lung Function Interpretation Does Not Alter Correlation to Symptom Burden in Asthma. Am J Respir Crit Care Med. 211(Abstracts):a7144–a7144.

  4. Witonsky WJ, Gorla GA, Elhawary EJ, Chen CZ, Mefford MJ, Perez-Garcia PJ, Huntsman HS, Hu HD, Eng EC, Woodruff WP, Sankararaman SS, Ziv ZE, Flint FJ, Zaitlen ZN, Burchard BE, Rahmani RE. Contrastive Machine Learning Reveals the Molecular Profile of Omalizumab Responders in Type 2 Asthma. Am J Respir Crit Care Med. 211(Abstracts):a7771–a7771.

  5. Farooqui FO, Elicker EB, Henry HT, Hahn HL, Kallianos KK, Han HM, Barr BR, Comellas CA, Bon BJ, Onofrei OC, Hansel HN, Wells WJ, Paine PR, Barjaktarevic BI, Woodruff WP, Fahy FJ. The Size and Location Features of Mucus Plugs in COPD Differ Depending on the Extent of Emphysema. Am J Respir Crit Care Med. 211(Abstracts):a3365–a3365.

  6. Steinberg ST, Auyeung AV, Fernandez-Hernandez FH, Koh KK, Ghosh GA, Olivier OA, Backes BB, Erle ED, Woodruff WP, Papa PF. IRE1a Regulation of Airway Epithelial Fate and Mucus Metaplasia. Am J Respir Crit Care Med. 211(Abstracts):a2485–a2485.

  7. Baugh BA, Albirair AM, Seedahmed SM, Sheshadri SA, Rajaram RR, Ost OD, Bonner BS, Thakur TN, Woodruff WP, Arjomandi AM. The Use of Cardiopulmonary Exercise Testing in the Pre-operative Evaluation of Lobectomy Patients Within the Veterans Health Administration. Am J Respir Crit Care Med. 211(Abstracts):a5566–a5566.

  8. Lafon LD, Hu HK, Rocco RA, Kaner KR, Ortega OV, Woodruff WP, Christenson CS, Martinez MF, Krishnan KJ, Paine PR, Meyers MD, Putcha PN, Curtis CJ, Labaki LW, Pandey PJ, Nahm NM, Chong CZ, McDonald MM. Single Nucleotide Variants in the Fc Receptor for IgG Are Associated With COPD Severity and Exacerbations in African American Participants From COPDGene and SPIROMICS. Am J Respir Crit Care Med. 211(Abstracts):a3188–a3188.

  9. Cao CS, Guerra GS, Zein ZJ, Christenson CS, Castro CM, Denlinger DL, Fahy FJ, Gaston GB, Hastie HA, Israel IE, Levy LB, Mauger MD, Wenzel WS, Woodruff WP, Meyers MD, Bleecker BE, Ortega OV. A Four-gene CC16-associated Transcriptomic Score and Risk for Asthma Exacerbations. Am J Respir Crit Care Med. 211(Abstracts):a2488–a2488.